Cellular and molecular mechanisms of endothelial dysfunction in diabetes
نویسندگان
چکیده
منابع مشابه
Cellular and molecular mechanisms of endothelial dysfunction in diabetes.
In healthy individuals, the vascular endothelium regulates an intricate balance of factors that maintain vascular homeostasis and normal arterial function. Functional disruption of the endothelium is known to be an early event that underlies the development of subsequent cardiovascular disease (CVD) including atherosclerosis and coronary heart disease. In addition, the rising global epidemic of...
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Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. This condition increases the risk of developing coronary, cerebrovascular, and peripheral arterial disease fourfold. Endothelial dysfunction is a major contributor to the pathogenesis of vascular disease in diabetes mellitus patients and has recently received increased attention. In this review article, some re...
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متن کاملMechanisms underlying endothelial dysfunction in diabetes mellitus.
Incubation of endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as superoxide production. The underlying mechanisms remain unknown. To address this issue in an in vivo model, diabetes was induced with streptozotocin in rats. Streptozotocin treatment led to endothelial dysfunction ...
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ژورنال
عنوان ژورنال: Diabetes and Vascular Disease Research
سال: 2013
ISSN: 1479-1641,1752-8984
DOI: 10.1177/1479164113500680